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As part of palliative care for a cancer patient, Czech experts froze part of the painful skin tumor on his back. However, within a few months, they found that the patient had lost all metastases and had completely recovered from the cancer. After cryotherapy, a reduction in tumor mass can be expected, but it is not common for this to trigger an overall (immune) response outside the low temperature site,” he explained. Kodet’s colleague Lukáš Lacina.
Experts add that while this phenomenon has already been documented in radiotherapy, in conjunction with cryotherapy, this is the first documented case of this mechanism in clinical practice. According to the Prague Medical Faculty, the systemic reaction probably occurred due to a combination of drugs and tumor freezing. According to doctors, this case suggests treatment options, but experts are careful. “Unfortunately, there are currently no known parameters, so-called biomarkers, according to which it would be possible to estimate in advance which of the patients responds so favorably to cryotherapy combined with systemic oncological immunotherapy. It would certainly be too optimistic to expect such an effect in all patients the benefit could be great, “Lacina said.
